TWNK Antibody

Size

100ug

Clone Number

Aliases

Ataxin 8 antibody; Ataxin8 antibody; ATXN 8 antibody; ATXN8 antibody; C10 orf2 antibody; C10orf 2 antibody; C10orf2 antibody; Chromosome 10 open reading frame 2 antibody; IOSCA antibody; mitochondrial antibody; MTDPS7 antibody; PEO 1 antibody; PEO antibody; PEO1 antibody; PEO1_HUMAN antibody; PEOA3 antibody; Progressive external ophthalmoplegia 1 protein antibody; SANDO antibody; SCA 8 antibody; SCA8 antibody; T7 gp4 like protein with intramitochondrial nucleoid localization antibody; T7 gp4-like protein with intramitochondrial nucleoid localization antibody; T7 helicase-related protein with intramitochondrial nucleoid localization antibody; T7 like mitochondrial DNA helicase antibody; T7-like mitochondrial DNA helicase antibody; Twinkle protein antibody; Twinkle protein, mitochondrial antibody; TWINL antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96RR1

Immunogen

Recombinant Human Twinkle protein, mitochondrial protein (559-684AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000

Background

Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TWNK

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience