TWIST1 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

ACS3 antibody; B-HLH DNA binding protein antibody; bHLHa38 antibody; BPES2 antibody; BPES3 antibody; Class A basic helix-loop-helix protein 38 antibody; CRS antibody; CRS1 antibody; CSO antibody; H-twist antibody; OTTHUMP00000116043 antibody; SCS antibody; Twist basic helix loop helix transcription factor 1 antibody; Twist family bHLH transcription factor 1 antibody; Twist homolog 1 (Drosophila) antibody; Twist homolog 1 antibody; TWIST homolog of drosophila antibody; Twist related protein 1 antibody; Twist-related protein 1 antibody; TWIST1 antibody; TWST1_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q15672

Immunogen

Recombinant Human Twist-related protein 1 protein (1-80AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TWIST1

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cardiovascular; Developmental biology; Stem cells