TUSC3 Antibody

Size

100ug

Clone Number

Aliases

TUSC3 antibody; N33Tumor suppressor candidate 3 antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 antibody; Oligosaccharyl transferase subunit TUSC3 antibody; Magnesium uptake/transporter TUSC3 antibody; Protein N33 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13454

Immunogen

Recombinant Human Tumor suppressor candidate 3 protein (42-196AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500

Background

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TUSC3

Research Areas

Cancer; Tags & Cell Markers