TTI1 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

TTI1 antibody; KIAA0406 antibody; SMG10 antibody; TELO2-interacting protein 1 homolog antibody; Protein SMG10 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43156

Immunogen

Recombinant Human TELO2-interacting protein 1 homolog protein (692-858AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TTI1

Research Areas

Epigenetics and Nuclear Signaling; Cell biology