TTBK2 Antibody

Size

100ul

Clone Number

Aliases

TTBK2 antibody; KIAA0847 antibody; Tau-tubulin kinase 2 antibody; EC 2.7.11.1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q6IQ55

Immunogen

Recombinant Human Tau-tubulin kinase 2 protein (1185-1244AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TTBK2

Research Areas

Neuroscience; Signal transduction