TRPV6 Antibody

Size

100ug

Clone Number

Aliases

ABP/ZF antibody; ABPZF antibody; Alu binding protein with zinc finger domain antibody; Calcium channel CaT1 antibody; Calcium transport protein 1 antibody; CaT L antibody; CaT Like antibody; CaT-L antibody; CaT-like antibody; CaT1 antibody; ecac antibody; ECaC2 antibody; Epithelial apical membrane calcium transporter/channel CaT1 antibody; Epithelial calcium channel 2 antibody; Epithelial calcium channel antibody; HSA277909 antibody; LP6728 antibody; MGC162545 antibody; NUDC antibody; Transient receptor potential cation channel subfamily V member 6 antibody; TrpV6 antibody; TRPV6_HUMAN antibody; ZFAB antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9H1D0

Immunogen

Recombinant Human Transient receptor potential cation channel subfamily V member 6 protein (620-764AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRPV6

Research Areas

Others