TRPM8 Antibody

Size

100ul

Clone Number

Aliases

Long transient receptor potential channel 6 antibody; LTrpC-6 antibody; LTrpC6 antibody; MGC2849 antibody; Short form of the TRPM8 cationic channel antibody; Transient receptor potential cation channel subfamily M member 8 antibody; Transient receptor potential p8 antibody; transient receptor potential-p8 antibody; Trp p8 antibody; Trp-p8 antibody; Trpm8 antibody; TRPM8_HUMAN antibody; TRPP8 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q7Z2W7

Immunogen

Recombinant Human Transient receptor potential cation channel subfamily M member 8 protein (980-1104AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRPM8

Research Areas

Neuroscience; Cancer; Metabolism; Signal transduction