TRPM7 Antibody

Size

100ul

Clone Number

Aliases

ALSPDC antibody; CHAK antibody; CHAK1 antibody; Channel kinase 1 antibody; Channel-kinase 1 antibody; Long transient receptor potential channel 7 antibody; LTrpC-7 antibody; LTrpC7 antibody; Transient receptor potential cation channel subfamily M member 7 antibody; TRP PLIK antibody; TRPM7 antibody; TRPM7_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96QT4

Immunogen

Recombinant Human Transient receptor potential cation channel subfamily M member 7 protein (756-855AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRPM7

Research Areas

Neuroscience