Troponin I-C(Phospho Ser22/S23) Polyclonal Antibody

Ab type

Primary antibody

Background

Troponin I (TnI)| along with troponin T (TnT) and troponin C (TnC)| is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: tnI-skeletal-fast-twitch| TnI-skeletal-slow-twitch| and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Reactivity

Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from mouse TNNI3 around the phosphorylation site of Ser22 and Ser23. AA range:5-54

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

24008

synonyms

Troponin I cardiac muscle; TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac troponin I