TRIM33 Antibody

Size

100ug

Clone Number

Aliases

8030451N04Rik antibody; AI413936 antibody; cb1085 antibody; DKFZp586K1123 antibody; E3 ubiquitin-protein ligase TRIM33 antibody; EC 6.3.2.- antibody; Ectodermin antibody; Ectodermin homolog antibody; FLJ11429 antibody; FLJ32925 antibody; id:ibd2175 antibody; MGC136680 antibody; mKIAA1113 antibody; OTTHUMP00000013662 antibody; OTTHUMP00000013663 antibody; Protein Rfg7 antibody; PTC7 antibody; Ret fused gene 7 antibody; RET-fused gene 7 protein antibody; RFG7 antibody; Rfg7 protein antibody; TF1G antibody; TIF1 gamma antibody; TIF1-gamma antibody; TIF1G antibody; TIF1GAMMA antibody; TIFGAMMA antibody; Transcription intermediary factor 1-gamma antibody; Transcriptional intermediary factor 1 gamma antibody; TRI33_HUMAN antibody; trim33 antibody; Tripartite motif containing 33 antibody; Tripartite motif containing 33 protein antibody; tripartite motif-containing 33 antibody; Tripartite motif-containing protein 33 antibody; wu:fc17f10 antibody; zgc:136680 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UPN9

Immunogen

Recombinant Human E3 ubiquitin-protein ligase TRIM33 protein (1-273AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRIM33

Research Areas

Epigenetics and Nuclear Signaling; Stem cells