TRIM27 Antibody

Size

100ul

Clone Number

Aliases

AW538890 antibody; DAAP-182E11.3 antibody; MGC189472 antibody; OTTHUMP00000029314 antibody; Ret finger protein antibody; RFP antibody; RFP transforming protein antibody; Rfp1 antibody; RING finger protein 76 antibody; RNF76 antibody; TRI27_HUMAN antibody; TRIM 27 antibody; Trim27 antibody; Tripartite motif containing 27 antibody; Tripartite motif containing protein 27 antibody; Tripartite motif protein TRIM27 antibody; Tripartite motif-containing protein 27 antibody; Zinc finger protein RFP antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P14373

Immunogen

Recombinant Human Zinc finger protein RFP protein (214-513AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of \\\'Lys-48\\\'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of \\\'Lys-63\\\'-linked polyubiquitin chains at \\\'Lys-220\\\' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRIM27

Research Areas

Epigenetics and Nuclear Signaling