TRIM25 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

E3 ubiquitin/ISG15 ligase TRIM25 antibody; EFP antibody; Estrogen responsive finger protein antibody; Estrogen-responsive finger protein antibody; RING finger protein 147 antibody; RNF 147 antibody; RNF147 antibody; TRI25 antibody; TRI25_HUMAN antibody; TRIM 25 antibody; Trim25 antibody; Tripartite motif containing 25 antibody; Tripartite motif containing protein 25 antibody; Tripartite motif protein TRIM25 antibody; Tripartite motif-containing protein 25 antibody; Tripartite motifcontaining25 antibody; Ubiquitin/ISG15-conjugating enzyme TRIM25 antibody; Z147 antibody; Zinc finger protein 147 (estrogen responsive finger protein) antibody; Zinc finger protein 147 antibody; Zinc finger protein-147 antibody; ZNF 147 antibody; ZNF147 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q14258

Immunogen

Recombinant Human E3 ubiquitin/ISG15 ligase TRIM25 protein (81-272AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates \'Lys-63\'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRIM25

Research Areas

Epigenetics and Nuclear Signaling; Cell biology; Signal transduction