TRIM13 Antibody

Size

100ul

Clone Number

Aliases

B cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody; B-cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody; CAR antibody; DLEU5 antibody; E3 ubiquitin-protein ligase TRIM13 antibody; HGNC:9976 antibody; LEU5 antibody; Leukemia associated protein 5 antibody; Leukemia-associated protein 5 antibody; Putative tumor suppressor RFP2 antibody; Ret finger protein 2 antibody; RFP2 antibody; RING finger protein 77 antibody; RNF77 antibody; TRI13_HUMAN antibody; Trim13 antibody; Tripartite motif protein 13 antibody; Tripartite motif-containing protein 13 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O60858

Immunogen

Recombinant Human E3 ubiquitin-protein ligase TRIM13 protein (40-310AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRIM13

Research Areas

Epigenetics and Nuclear Signaling; Cell biology; Signal transduction