TRIB3 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

C20orf97 antibody; Neuronal cell death inducible putative kinase antibody; Neuronal cell death-inducible putative kinase antibody; NIPK antibody; p65 interacting inhibitor of NF-kappaB antibody; p65-interacting inhibitor of NF-kappa-B antibody; SINK antibody; SKIP 3 antibody; SKIP3 antibody; TRB 3 antibody; TRB-3 antibody; TRB3 antibody; TRIB 3 antibody; Trib3 antibody; TRIB3_HUMAN antibody; Tribbles homolog 3 antibody; Tribbles pseudokinase 3 antibody; Tribbles3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96RU7

Immunogen

Recombinant Human Tribbles homolog 3 protein (152-325AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the \\\'Thr-308\\\' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRIB3

Research Areas

Cardiovascular; Cell biology; Signal transduction