TRIB3 Antibody

Size

100ug

Clone Number

Aliases

C20orf97 antibody; Neuronal cell death inducible putative kinase antibody; Neuronal cell death-inducible putative kinase antibody; NIPK antibody; p65 interacting inhibitor of NF-kappaB antibody; p65-interacting inhibitor of NF-kappa-B antibody; SINK antibody; SKIP 3 antibody; SKIP3 antibody; TRB 3 antibody; TRB-3 antibody; TRB3 antibody; TRIB 3 antibody; Trib3 antibody; TRIB3_HUMAN antibody; Tribbles homolog 3 antibody; Tribbles pseudokinase 3 antibody; Tribbles3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96RU7

Immunogen

Recombinant Human Tribbles homolog 3 protein (152-325AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the \\\'Thr-308\\\' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TRIB3

Research Areas

Cardiovascular; Cell biology; Signal transduction