TPX2 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

C20ORF1 antibody; C20orf2 antibody; Chromosome 20 Open Reading Frame 1 antibody; Differentially expressed in cancerous and non-cancerous lung cells 2 antibody; Differentially expressed in cancerous and noncancerous lung cells 2 antibody; Differentially expressed in lung cells 2 antibody; Differentially expressed in lung cells antibody; DIL 2 antibody; DIL-2 antibody; DIL2 antibody; FLS353 antibody; GD:C20orf1 antibody; HCA 519 antibody; HCA519 antibody; HCTP 4 antibody; HCTP4 antibody; Hepatocellular carcinoma associated antigen 519 antibody; Hepatocellular carcinoma-associated antigen 519 antibody; p100 antibody; Preferentially expressed in colorectal cancer antibody; Protein fls353 antibody; REPP 86 antibody; repp86 antibody; Restricted expression proliferation associated protein 100 antibody; Restricted expression proliferation-associated protein 100 antibody; Targeting protein for Xklp2 antibody; TPX 2 antibody; TPX2 antibody; TPX2 microtubule associated homolog antibody; TPX2 microtubule associated protein homolog antibody; TPX2 microtubule nucleation factor antibody; TPX2_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9ULW0

Immunogen

Recombinant Human Targeting protein for Xklp2 protein (160-320AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at \'Thr-288\' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TPX2

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cell biology