TP53 Monoclonal Antibody

Size

Clone Number

Aliases

P53; LFS1; TRP53; TP53

Immunogen Species

Human

UniProt ID

P04637

Immunogen

Purified recombinant human p53 protein fragments expressed in E.coli.

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA,WB;Recommended dilution:WB:1:500-1:5000

Background

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Clonality

Monoclonal

Isotype

IgG2b

Purification Method

Affinity purified

Conjugate

Non-conjugated

Buffer

Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TP53

Research Areas

Epigenetics and Nuclear Signaling;Cancer;Cell biology