TOR1A Antibody

Size

100ug

Clone Number

Aliases

DQ2 antibody; Dystonia 1 antibody; Dystonia 1 protein antibody; Dystonia 1 torsion antibody; Dyt1 antibody; TOR1A antibody; TOR1A_HUMAN antibody; Torsin 1A antibody; Torsin A antibody; Torsin family 1 member A antibody; Torsin family 1, member A (torsin A) antibody; Torsin-1A antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O14656

Immunogen

Recombinant Human Torsin-1A protein (88-125AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TOR1A

Research Areas

Neuroscience