TNK1(Phospho-Tyr277) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways| mediating cellular proliferation| survival| and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues| thus may function in signaling pathways utilized broadly during fetal development| and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway| and knockout mice have been shown to develop spontaneous tumors| suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human TNK1 (Tyr277)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

TNK1 ;Tyr277 ; Non-receptor tyrosine-protein kinase TNK1; EC 2.7.10.2; CD38 negative kinase 1