TNFSF11 Antibody

Size

100ug

Clone Number

Aliases

CD254 antibody; hRANKL2 antibody; ODF antibody; OPGL antibody; OPTB2 antibody; Osteoclast differentiation factor antibody; Osteoprotegerin ligand antibody; RANKL antibody; Receptor activator of NF-kappa-B ligand antibody; Receptor activator of nuclear factor kappa B ligand antibody; Receptor activator of nuclear factor kappa-B ligand antibody; sOdf antibody; soluble form antibody; TNF-related activation-induced cytokine antibody; TNF11_HUMAN antibody; Tnfsf11 antibody; TRANCE antibody; Tumor necrosis factor (ligand) superfamily member 11 antibody; Tumor necrosis factor ligand superfamily member 11 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O14788

Immunogen

Recombinant Human Tumor necrosis factor ligand superfamily member 11 protein (73-306AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TNFSF11

Research Areas

Cardiovascular; Immunology