TMEM59 Antibody

Size

100ug

Clone Number

Aliases

C1orf8 antibody; HSPC001 antibody; Liver membrane-bound protein antibody; TMEM59 antibody; TMEM59 transmembrane protein 59 antibody; TMM59_HUMAN antibody; Transmembrane protein 59 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BXS4

Immunogen

Recombinant Human Transmembrane protein 59 protein (59-201AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

Background

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TMEM59

Research Areas

Neuroscience; Tags & Cell Markers; Signal transduction