TLR3 Antibody

Size

100ug

Clone Number

Aliases

CD283 antibody; CD283 antigen antibody; IIAE2 antibody; TLR 3 antibody; Tlr3 antibody; TLR3_HUMAN antibody; Toll Like Receptor 3 antibody; Toll-like receptor 3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O15455

Immunogen

Recombinant Human Toll-like receptor 3 protein (135-297AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TLR3

Research Areas

Immunology; Microbiology; Signal transduction