TLR1 Antibody

Size

100ug

Clone Number

Aliases

CD281 antibody; CD281 antigen antibody; KIAA0012 antibody; LPRS5 antibody; rsc786 antibody; TIL antibody; TIL. LPRS5 antibody; Tlr1 antibody; TLR1_HUMAN antibody; Toll (Drosophila) homolog antibody; Toll like receptor 1 antibody; Toll-like receptor 1 antibody; Toll/interleukin-1 receptor-like protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q15399

Immunogen

Recombinant Human Toll-like receptor 1 protein (25-580AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TLR1

Research Areas

Immunology; Signal transduction