TLK1(Phospho Ser764) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|enzyme regulation:Cell-cycle regulated| maximal activity in S-phase. Inactivated by phosphorylation at Ser-743| potentially by CHK1.|Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23| augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro| phosphorylates histone H3 at 'Ser-10'.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|Contains 1 protein kinase domain.|subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.|tissue specificity:Widely expressed. Present in fetal placenta| liver| kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.|

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human TLK1 (Phospho Ser764)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

TLK1 ;Phospho Ser764