TINF2 Antibody

Size

100ul

Clone Number

5G11

Aliases

TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2), TINF2, TIN2

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BSI4

Immunogen

A synthesized peptide derived from human Tin2

Raised in

Species Reactivity

Human, Mouse, Rat

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.

Clonality

Monoclonal

Isotype

Rabbit IgG

Purification Method

Affinity-chromatography

Conjugate

Non-conjugated

Buffer

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TINF2

Research Areas

Epigenetics and Nuclear Signaling