Tie-1 Polyclonal Antibody

Ab type

Primary antibody

Background

TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TIE1.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human TIE1. AA range:851-900

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

125090

synonyms

TIE1; TIE; Tyrosine-protein kinase receptor Tie-1