TICAM2 Antibody

Size

100ul

Clone Number

Aliases

Putative NF-kappa-B-activating protein 502 antibody; TCAM2_HUMAN antibody; TICAM-2 antibody; TICAM2 antibody; TIR containing adapter molecule 2 antibody; TIR domain containing adaptor protein antibody; TIR domain-containing adapter molecule 2 antibody; TIRAP 3 antibody; TIRAP3 antibody; TIRAP3a short form antibody; TIRP antibody; Toll-like receptor adaptor protein 3 antibody; Toll/interleukin-1 receptor domain-containing protein antibody; TRAM antibody; TRIF-related adapter molecule antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q86XR7

Immunogen

Recombinant Human TIR domain-containing adapter molecule 2 protein (1-235AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TICAM2

Research Areas

Immunology