TGFBR2 Antibody

Size

100ug

Clone Number

Aliases

AAT3 antibody; FAA3 antibody; LDS1B antibody; LDS2 antibody; LDS2B antibody; MFS2 antibody; RIIC antibody; TAAD2 antibody; TbetaR II antibody; TbetaR-II antibody; TGF beta receptor type 2 antibody; TGF beta receptor type II antibody; TGF beta receptor type IIB antibody; TGF beta type II receptor antibody; TGF-beta receptor type II antibody; TGF-beta receptor type-2 antibody; TGF-beta type II receptor antibody; TGF-beta-R2 antibody; TGFB R2 antibody; TGFbeta - RII antibody; TGFbeta RII antibody; Tgfbr2 antibody; TGFR-2 antibody; TGFR2_HUMAN antibody; Transforming growth factor beta receptor II antibody; Transforming growth factor beta receptor type II antibody; Transforming growth factor beta receptor type IIC antibody; Transforming growth factor, beta receptor II (70/80kDa) antibody; transforming growth factor, beta receptor II alpha antibody; transforming growth factor, beta receptor II beta antibody; transforming growth factor, beta receptor II delta antibody; transforming growth factor, beta receptor II epsilon antibody; transforming growth factor, beta receptor II gamma antibody; Transforming growth factor-beta receptor type II antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P37173

Immunogen

Recombinant Human TGF-beta receptor type-2 protein (25-159AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TGFBR2

Research Areas

Signal transduction; Stem cells