Tgfb1 Antibody

Size

100ug

Clone Number

Aliases

Tgfb1 antibody; Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide antibody; LAP); Transforming growth factor beta-1 antibody; TGF-beta-1)] antibody

Immunogen Species

Mus musculus (Mouse)

UniProt ID

P04202

Immunogen

Recombinant Mouse Transforming growth factor beta-1 protein (30-278AA)

Raised in

Rabbit

Species Reactivity

Mouse, Human

Tested Applications

ELISA, WB, IP; Recommended dilution: WB:1:500-1:5000, IP:1:200-1:2000

Background

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

Tgfb1

Research Areas

Cancer; Cardiovascular; Metabolism; Signal transduction; Stem cells