TET2 Antibody

Size

100ul

Clone Number

Aliases

FLJ20032 antibody; KIAA1546 antibody; MDS antibody; Methylcytosine dioxygenase TET2 antibody; Nbla00191 antibody; Probable methylcytosine dioxygenase TET2 antibody; Protein Ayu17 449 antibody; Tet 2 antibody; Tet methylcytosine dioxygenase 2 antibody; Tet oncogene 2 antibody; Tet oncogene family member 2 antibody; TET2 antibody; TET2_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q6N021

Immunogen

Recombinant Human Methylcytosine dioxygenase TET2 protein (1833-2002AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TET2

Research Areas

Epigenetics and Nuclear Signaling