TERF2IP Antibody

Size

100ul

Clone Number

Aliases

Dopamine receptor interacting protein 5 antibody; Dopamine receptor-interacting protein 5 antibody; DRIP 5 antibody; DRIP5 antibody; hRap1 antibody; MGC105533 antibody; RAP 1 antibody; RAP1 homolog antibody; RAP1, yeast, homolog if antibody; RAP1, yeast, homolog of antibody; Repressor/activator protein 1 homolog antibody; TE2IP_HUMAN antibody; Telomeric Repeat Binding Factor 2 Interacting Protein antibody; Telomeric repeat-binding factor 2-interacting protein 1 antibody; TERF2-interacting protein antibody; TERF2-interacting telomeric protein 1 antibody; TERF2IP antibody; TRF2 Interacting Telomeric Protein RAP1 antibody; TRF2 interacting telomeric RAP1 protein antibody; TRF2-interacting telomeric protein 1 antibody; TRF2-interacting telomeric protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NYB0

Immunogen

Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1 protein (1-280AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5\\\'-TTAGGG-3\\\' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5\\\'-TTAGGG-3\\\' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TERF2IP

Research Areas

Epigenetics and Nuclear Signaling; Tags & Cell Markers