TEAD1 Antibody

Size

100ul

Clone Number

Aliases

AA antibody; Atrophia areata peripapillary chorioretinal degeneration antibody; NTEF 1 antibody; NTEF-1 antibody; NTEF1 antibody; Protein GT IIC antibody; Protein GT-IIC antibody; REF 1 antibody; REF1 antibody; SV40 transcriptional enhancer factor antibody; TCF 13 antibody; TCF-13 antibody; TCF13 antibody; TEA domain family member antibody; TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody; TEA domain family member 1 antibody; TEAD 1 antibody; TEAD 1 protein antibody; TEAD-1 antibody; TEAD1 antibody; TEAD1 protein antibody; TEAD1_HUMAN antibody; TEF 1 antibody; TEF1 antibody; Transcription factor 13 (SV40 transcriptional enhancer factor) antibody; Transcription factor 13 antibody; Transcriptional enhancer factor 1 antibody; Transcriptional enhancer factor TEF-1 antibody; Transcriptional enhancer factor TEF1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P28347

Immunogen

Recombinant Human Transcriptional enhancer factor TEF-1 protein (135-215AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:500, IF:1:50-1:200

Background

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC \\\'enhansons\\\' (5\\\'-GTGGAATGT-3\\\') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TEAD1

Research Areas

Epigenetics and Nuclear Signaling; Cardiovascular