TDRD12 Antibody

Size

100ug

Clone Number

Aliases

ECAT8 antibody; ES cell associated transcript 8 antibody; ES cell-associated transcript 8 protein antibody; TDR12_HUMAN antibody; Tdrd12 antibody; Tudor domain containing 12 antibody; Tudor domain-containing protein 12 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q587J7

Immunogen

Recombinant Human Putative ATP-dependent RNA helicase TDRD12 protein (991-1164AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TDRD12

Research Areas

Epigenetics and Nuclear Signaling