TDP1 Antibody

Size

100ul

Clone Number

Aliases

AI838772 antibody; AW493413 antibody; FLJ11090 antibody; MGC104252 antibody; MGC112732 antibody; RP24-311F12.2 antibody; SCAN1 antibody; TDP1 antibody; TYDP antibody; TYDP1_HUMAN antibody; Tyr-DNA phosphodiesterase 1 antibody; Tyrosyl-DNA phosphodiesterase 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NUW8

Immunogen

Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3\\\'-phosphodiester bond, giving rise to DNA with a free 3\\\' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3\\\'-phosphoglycolates on protruding 3\\\' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3\\\'exonuclease activity and can remove a single nucleoside from the 3\\\'end of DNA and RNA molecules with 3\\\'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3\\\'phosphate.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TDP1

Research Areas

Epigenetics and Nuclear Signaling