TCPR2 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family| and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy| as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR)| which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human TCPR2

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

155210

synonyms

TCPR2