TARBP2 Antibody

Size

100ul

Clone Number

Aliases

LOQS antibody; Prbp antibody; RISC loading complex subunit TARBP2 antibody; RISC-loading complex subunit tarbp2 antibody; TAR (HIV 1) RNA binding protein 2 antibody; TAR (HIV) RNA binding protein 2 antibody; TAR (HIV) RNA-binding protein TRBP1 antibody; TAR RNA Binding Protein 2 antibody; TAR RNA-binding protein 2 antibody; tarbp2 antibody; TARBP2 RISC loading complex RNA binding subunit antibody; Trans-activation-responsive RNA-binding protein antibody; TRBP antibody; TRBP1 antibody; TRBP2 antibody; TRBP2_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q15633

Immunogen

Recombinant Human RISC-loading complex subunit TARBP2 protein (1-366AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TARBP2

Research Areas

Epigenetics and Nuclear Signaling; Microbiology