tal1 Antibody

Size

100ug

Clone Number

Aliases

tal1 antibody; scl antibody; tal-1 antibody; si:ch211-135j1.3 antibody; T-cell acute lymphocytic leukemia protein 1 homolog antibody; TAL-1 antibody; Stem cell protein antibody; zSCL antibody

Immunogen Species

Zebrafish

UniProt ID

O93507

Immunogen

Recombinant Zebrafish T-cell acute lymphocytic leukemia protein 1 homolog protein (1-324AA)

Raised in

Rabbit

Species Reactivity

Zebrafish

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

tal1

Research Areas

Others