TAB2(Phospho-Ser372) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is an activator of MAP3K7/TAK1| which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6| MAP3K7 and TAB1| and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein| along with TAB1 and MAP3K7| also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK)| which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects| multiple types| 2 (CHTD2). Alternative splicing results in multiple transcript variants.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human TAB2 (Ser372)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

TAB2 ;Ser372 ; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2