SYVN1 Antibody

Size

100ug

Clone Number

Aliases

1200010C09Rik antibody; DER3 antibody; E3 ubiquitin-protein ligase synoviolin antibody; HMG coA reductase degradation 1 homolog antibody; HRD1 antibody; KIAA1810 antibody; MGC40372 antibody; OTTHUMP00000230429 antibody; OTTHUMP00000230430 antibody; OTTHUMP00000230431 antibody; OTTHUMP00000230432 antibody; Synovial apoptosis inhibitor 1 antibody; Synovial apoptosis inhibitor 1; synoviolin antibody; Synoviolin 1 antibody; Synoviolin 1 isoform b antibody; SYNOVIOLIN antibody; SYVN1 antibody; SYVN1_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q86TM6

Immunogen

Recombinant Human E3 ubiquitin-protein ligase synoviolin protein (338-487AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SYVN1

Research Areas

Epigenetics and Nuclear Signaling; Cell biology