SUMO2 Antibody, FITC conjugated

Size

100ug

Clone Number

Aliases

HSMT 3 antibody; HSMT3 antibody; MGC117191 antibody; Sentrin 2 antibody; Sentrin-2 antibody; Sentrin2 antibody; Small ubiquitin like modifier 2 antibody; Small ubiquitin related modifier 2 antibody; Small ubiquitin-related modifier 2 antibody; SMT 3B antibody; SMT3 homolog 2 antibody; SMT3 suppressor of mif two 3 homolog 2 antibody; SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) antibody; SMT3, yeast, homolog 2 antibody; Smt3A antibody; SMT3B antibody; SMT3H2 antibody; SUMO-2 antibody; SUMO-3 antibody; SUMO2 antibody; SUMO2_HUMAN antibody; Sumo3 antibody; Ubiquitin like protein SMT3B antibody; Ubiquitin-like protein SMT3A antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P61956

Immunogen

Recombinant Human Small ubiquitin-related modifier 2 protein (1-84AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

Background

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

FITC

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SUMO2

Research Areas

Epigenetics and Nuclear Signaling; Cell biology