Stat4 Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human Stat4 around the non-phosphorylation site of Y693.

Storage Stability

-20°C for 1 year

Concentration

MolecularWeight_Da

synonyms

Signal transducer and activator of transcription 4; STAT4; Signal transducer and activator of transcription 4