SSTR2 Antibody

Size

100ul

Clone Number

1C3

Aliases

Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1), SSTR2

Immunogen Species

Homo sapiens (Human)

UniProt ID

P30874

Immunogen

A synthesized peptide derived from human Somatostatin Receptor 2

Raised in

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:50-1:200

Background

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Clonality

Monoclonal

Isotype

Rabbit IgG

Purification Method

Affinity-chromatography

Conjugate

Non-conjugated

Buffer

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SSTR2

Research Areas

Neuroscience; Cancer; Metabolism