SSRP1 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is a subunit of a heterodimer that| along with SUPT16H| forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described| but its full-length nature is not known.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human SSRP1

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

77990

synonyms

SSRP1