SRSF1 Antibody

Size

100ul

Clone Number

Aliases

Alternative splicing factor 1 antibody; Alternative-splicing factor 1 antibody; arginine/serine-rich 1 antibody; ASF 1 antibody; ASF antibody; ASF-1 antibody; ASF1 antibody; FLJ53078 antibody; MGC5228 antibody; P33 subunit antibody; Pre mRNA splicing factor SF2 P33 subunit antibody; pre-mRNA-splicing factor SF2 antibody; Serine/arginine-rich splicing factor 1 antibody; SF2 antibody; SF2P33 antibody; SFRS1 antibody; Splicing factor 2 alternate splicing factor antibody; Splicing factor 2 antibody; Splicing factor antibody; Splicing factor arginine/serine rich 1 antibody; SR Splicing factor 1 antibody; SRp30a antibody; srsf1 antibody; SRSF1_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q07955

Immunogen

Recombinant Human Serine/arginine-rich splicing factor 1 protein (1-248AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5\\\'- and 3\\\'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5\\\'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5\\\'-RGAAGAAC-3\\\' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5\\\'-CGAGGCG-3\\\' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SRSF1

Research Areas

Epigenetics and Nuclear Signaling