SRRT Antibody

Size

100ul

Clone Number

Aliases

ARS2 protein antibody; Arsenate resistance protein ARS2 antibody; Arsenite resistance protein 2 antibody; Arsenite resistance protein antibody; Arsenite-resistance protein 2 antibody; ASR2 antibody; MGC126427 antibody; Serrate antibody; Serrate RNA effector molecule antibody; Serrate RNA effector molecule homolog (Arabidopsis) antibody; Serrate RNA effector molecule homolog antibody; SRRT antibody; SRRT_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BXP5

Immunogen

Recombinant Human Serrate RNA effector molecule homolog protein (627-876AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SRRT

Research Areas

Cell biology; Metabolism; Signal transduction