SREBP-1(Phospho Ser439) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1)| which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage| the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor| and the mature nuclear form is rapidly catabolized| thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

Reactivity

Human, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human SREBP-1 around the phosphorylation site of Ser439. AA range:405-454

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

121675

synonyms

Sterol regulatory element-binding protein 1; SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1