SPTLC1 Polyclonal Antibody

Ab type

Primary antibody

Background

SPTLC1 encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The serine palmitoyltransferase long chain base subunit 1 is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from SPTLC1 . at AA range: 411-460

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

52030

synonyms

SPTLC1; LCB1; Serine palmitoyltransferase 1; Long chain base biosynthesis protein 1; LCB 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1