SPTLC1 Antibody

Size

100ul

Clone Number

Aliases

HSAN antibody; HSAN1 antibody; HSN1 antibody; LBC1 antibody; LCB 1 antibody; LCB1 antibody; Long chain base biosynthesis protein 1 antibody; MGC14645 antibody; Serine C palmitoyltransferase antibody; Serine palmitoyl CoA transferase 1 antibody; Serine palmitoyltransferase 1 antibody; Serine palmitoyltransferase long chain base subunit 1 antibody; Serine palmitoyltransferase subunit 1 antibody; Serine-palmitoyl-CoA transferase 1 antibody; SPT 1 antibody; SPT1 antibody; SPTC1_HUMAN antibody; SPTI antibody; SPTLC 1 antibody; SPTLC1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O15269

Immunogen

Recombinant Human Serine palmitoyltransferase 1 protein (37-310AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SPTLC1

Research Areas

Neuroscience; Cancer; Cardiovascular; Metabolism; Signal transduction