SPTA1 Antibody

Size

100ul

Clone Number

Aliases

Alpha I spectrin antibody; EL 2 antibody; EL2 antibody; Elliptocytosis 2 antibody; Elliptocytosis2 antibody; Erythrocyte alpha spectrin antibody; erythrocyte antibody; Erythroid alpha spectrin antibody; Erythroid alpha-spectrin antibody; Erythroid spectrin alpha antibody; HPP antibody; HS3 antibody; Spectrin alpha chain antibody; Spectrin alpha chain erythrocyte antibody; Spectrin alpha erythrocytic 1 antibody; SPH3 antibody; SPTA 1 antibody; SPTA antibody; SPTA1 antibody; SPTA1_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P02549

Immunogen

Synthetic peptide of Human SPTA1

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:60-1:450

Background

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.05% sodium azide, 40% glycerol, pH7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SPTA1

Research Areas