SphK2(Phospho Thr614) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human SPHK2 around the phosphorylation site of Thr614. AA range:580-629

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

69217

synonyms

Sphingosine kinase 2; SPHK2; Sphingosine kinase 2; SK 2; SPK 2